• Aloe Vera
• Avenanthramides
• Black & White Tea
• Blackberry
• Chamomile
• COFFEEBERRY^™
• Dill
• Feverfew
• Grape Seed Extract
• Green Tea
• Lavender
• Licorice
• Oats
• Olive Leaf
• Pomegranate
• Shea Butter
• Shiitake
• Silymarin
• Soy
• Wheat
• Willowherb
• Ylang-Ylang

Feverfew (Purified Feverfew Extract)

History and Origin

• Feverfew (Tanacetum parthenium) is a flower native to the Balkan Peninsula. Known also as Midsummer Daisy and Chrysanthemum parthenium, it was brought to America as an ornamental plant.
• Feverfew has been used for centuries. Records dating back 2,000 years cite it as a potential treatment for headaches. Its efficacy for lowering fevers was well documented.
• Other traditional uses include nerve relaxant, antispasmodic and remedy for stomach aches.
• Pharmacological, chemical and clinical studies over the past 15 years have confirmed the value of feverfew for the treatment of migraines, leading Health Canada to issue a Natural Health Product monograph for it as an herbal product for migraines.

Feverfew (Purified Feverfew Extract):

Feverfew and its crude extracts have anti-oxidant and other properties due to a significant number of components which include, but are not limited to, apigenin-7-glucoside, apigenin-7-glucuronide, 1-β-hydroxyarbusculin, 6-hydroxykaempferol-3,7-4'-trimethylether (Tanetin), 6-hydroxykaempferol-3,7-dimethyl ether, 8-β-reynosin, 10-epicanin, ascorbic acid, beta-carotene, calcium, chromium, chrysanthemolide, chrysanthemomin, chrysarten-A, chrsyarten-c, chrysoeriol-7-glucuronide, cobalt, cosmosiin, epoxyartemorin, luteolin-7-glucoside, luteolin-7-glucuronide, mangnoliolide, parthenolide, quercetagentin-3,7,3'-trimethylether, quercetagetin-3'7-dimethylether, reynosin, tanaparthin, tanaparthin-1α,4α-epoxide, tanaparthin-1β,4β-epoxide, β-costunolide, 3-β-hydroxy-parthenolide, and 3,7,3'-trimethoxyquercetagetin1. Parthenolide, just one of feverfew's anti-oxidant components, is a potent skin sensitizer and therefore inappropriate for topical applications^2-6. To minimize the risk of skin sensitization from topical feverfew formulations, purification techniques were used to develop a Purified Feverfew Extract, a preparation with documented antioxidant activity and the ability to mitigate oxidative stress in skin caused by environmental insult.

Facial Tolerance of a Feverfew (Purified Feverfew Extract) Containing Daily Moisturizer Regimen⁷

A controlled, full-face, monadic study was performed to assess the facial tolerance of a Feverfew (Purified Feverfew Extract) containing daily moisturizer regimen vs baseline over a four-week period in females with dry, sensitive skin. Subjects applied each moisturizer daily to the entire face for four weeks:

• Facial day moisturizer with Feverfew (Purified Feverfew Extract) containing SPF 15 in the morning
• Facial night moisturizer with Feverfew (Purified Feverfew Extract) in the evening

Evaluations were conducted at baseline and at weeks 1, 2, and 4. These included:

• Clinical assessment by an expert grader on a 0-8 scale for several skin sensitivity parameters
• Subjects self-assessment for sensory sensitivity parameters and for appearance and feel of their facial skin
• Standardized digital imaging.

Visibly Reduces Redness and Calms Sensitive Skin⁷

The facial moisturizing regimen with Feverfew (Purified Feverfew Extract) was found to be mild, very well tolerated, and also led to visual and sensorial improvements in the skin.

Clinically Proven to Visibly Reduce Redness and Soothe Skin in Patients with Sensitive Skin⁸

Safety Profile

Proven Mildness in Over 1000 Subjects⁹

Ten Feverfew (Purified Feverfew Extract) formulations were topically evaluated in the Human Repeat Insult Patch Test. Each panel size was approximately 200 subjects in this topical test. There was no induction of dermal sensitization in any of the topical HRIPT tests with these Feverfew (Purified Feverfew Extract) formulations.

References

1. Use of feverfew extract for regulating skin aging factors. European Patent EP1367993. Martin KM, Saliou C, inventors. Publication date May 16, 2007.
2. Martin K, Sur R, Liebel F, Tierney N, Lyte P, Garay M, Oddos T, Athonavage M, Shapiro S, Southall M. Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression. Arch Dermatol Res.2008; 300:69–80.
3. Jain NK, Kulkarni SK. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. J Ethnopharmacol.1999; 68:251–259.
4. Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase.
   Chem Biol. 2001 8:759–766.
5. Hausen BM, Osmundsen PE. Contact allergy to parthenolide in Tanacetum parthenium (L.) Schulz-Bip. (feverfew, Asteraceae) and cross-reactions to related sesquiterpene lactone containing Compositae species. Acta Derm Venereol.1983; 63:308–314.
6. Paulsen E, Christensen LP, Andersen KE. Compositae dermatitis from airborne parthenolide.
   Br J Dermatol.2007; 156:510–515
7. Facial tolerance of a Feverfew (Purified Feverfew Extract) containing daily moisturizer regimen in mild to moderate rosacea patients. Poster presented at the 66^th Annual Meeting of the American Academy of Dermatology, February 2008.
8. In vitro testing, data on file Johnson & Johnson Consumer Companies, Inc.
9. Clinical Safety Review of Topical Emollient Formulations Containing Parthenolide-Free Extract of Feverfew, Poster presented at the 63^rd Annual Meeting of the American Academy of Pediatrics, February 2005.