Historically, grape seed extracts have been used in Europe for the treatment of circulatory disorders ranging from varicose veins to vascular insufficiency and atherosclerosis.1
Grape seed extract is rich in flavonoids such as proanthocyanidins which give it anti-oxidant activity. Proanthocyanidins are found also in green and black tea, pine bark, cranberry and black currant. Grape seed proanthocyanidins also contains resveratrol, a potent anti-oxidant contained in red wine.
Proanthocyanidins are reputed to be able to stabilize dermal collagen and elastin and thus to protect the elasticity and appearance of skin.1
Grape Seed Extract contains proanthocyanidins, which are very potent antioxidants, helpful for diminishing the sun's damaging effects and lessening free-radical damage.2,3 Grape Seed Extract has also been shown to have repairing properties.4 There has been no reported difference in the AO potential among different types of grapes.5
There have not been any significant reports of adverse effects from the use of topical cosmetic formulations containing grape seed extract. Flavonoids are typically not associated with cutaneous adverse effects.1
